Ryle is the brother of C. Hoffman, who, upon crossing the Breach, nearly dies from the experience. Ryle only survives due to his brother’s ability (with the help of a few Archanists) to reconstruct his body with machine parts. What remains is a man disconnected from the world, who never fully accepts or adapts to being more machine than human. This leads to numerous physiological issues that manifest themselves in his story and rules.
Ryle is named after British philosopher Gilbert Ryle. Gilbert Ryle wrote at length about the concept of a mind/body disconnect and in fact created the now popularized phrase “the ghost in the machine”. For him however, the machine was not literally mechanical, but rather the human machine. The “mind” was this ghost that didn’t quite fit, and regardless of what a person did, the mind remained in many ways separate from the body it inhabited.
Ryle is in all ways the personification of the theories created by Gilbert Ryle but takes on a much more literal form. Take a spin on Wikipedia through the concepts and links presented in the article for Gilbert Ryle, and you’ll find the inspiration for nearly every one of Ryle’s characteristics such as, but not limited to, “can’t connect” and “lack of empathy” (as well as quite a bit about Hoffman too). I suggest reading up on “category mistakes” while you’re at it!